Hippocampal damage associated with prolonged and fatal stress in primates
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چکیده
منابع مشابه
Hippocampal damage associated with prolonged and fatal stress in primates.
Sustained exposure to glucocorticoids (GCs), adrenal hormones secreted during stress, can cause neural degeneration in the rat. This is particularly so in the hippocampus, a principal neural target site for GCs, in which GCs can exacerbate the rate of neuron death during normal aging, as well as the severity of neuronal damage after various neurological insults. Thus, stress can be a potent mod...
متن کاملHippocampal damage associated with prolonged glucocorticoid exposure in primates.
In the laboratory rat and guinea pig, glucocorticoids (GCs), the adrenal steroids that are secreted during stress, can damage the hippocampus and exacerbate the hippocampal damage induced by various neurological insults. An open question is whether GCs have similar deleterious effects in the primate hippocampus. In fact, we showed that sustained and fatal stress was associated with preferential...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 1989
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.09-05-01705.1989